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商品描述

商品屬性

 RanbP3 Mouse Monoclonal Antibody (QYA10771)

產(chǎn)品名稱：RanbP3鼠單克隆抗體

貨號(hào)：QYA10771

 

主要參數(shù)

應(yīng)用：WB

適應(yīng)物種：Human, Mouse, Rat

分子量：70, 90KD

同種型：IgG1

儲(chǔ)存溫度：-20℃

建議工作濃度：WB:1000-2000

特異性：抗體可以檢測(cè)內(nèi)源性RanBP3蛋白

其他名稱：DKFZp58611520, RANB3

 

背景

作為XPO1/CRM1介導(dǎo)的核輸出的輔助因子，可能起輸出復(fù)合物支架蛋白作用。與XPO1/CRM1結(jié)合后，穩(wěn)定XPO1/CRM1與結(jié)合物的蛋白互作。在缺乏Ran結(jié)合型GTP的情況下，可阻止XPO1/CRM1與核孔復(fù)合體結(jié)合。與CHC1/RCC1結(jié)合并增加其鳥嘌呤核苷酸交換活性。以Ran依賴性方式將XPO1/CRM1募集至CHC1/RCC1。通過(guò)與R-SMAD蛋白(SMAD2和SMAD3)相互作用并介導(dǎo)其核輸出，成為TGF-β信號(hào)通路的負(fù)調(diào)控因子。

 

 

注：本產(chǎn)品僅用于科研用途，不用于診斷和治療。

Product name: RanbP3 Mouse Monoclonal Antibody

Cat: QYA10771

 

Main parameter

Applications: Western Blot (WB)

Reactivity: Human, Mouse, Rat

Protein MW: 70, 90 KD

Isotype: IgG1

Storage: -20℃

Recommended dilutions: WB:1000-2000

Specificity: Antibody can detects endogenous RanBP3 protein.

Alternative Names: DKFZp58611520, RANB3

 

Background

Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export. 

 

 

P.s. This product is only used for scientific research, not for diagnosis and treatment.